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The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signalling regulates various biological functions, including calcium and the metabolism of phosphorous, parathormone production, cell proliferation, and the control of innate and adaptive immunity.
A T > C base alteration in the promoter region of VDR variant rs11568820 eliminates the binding site for transcription factor Cdx2 that is upstream of exon 1e and leads to the production of a lower amount of protein and decreased transcriptional activity. The F allele of this variant is found in high numbers in Asians and Europeans and at a lower frequency in Sub-Saharan Africa.
The results of this study improve our understanding of how VDR gene polymorphisms modulate the response to dietary supplements containing calcitriol. Carriers of the TaqI and FF genotypes of the FokI polymorphisms show higher transcriptional activation and are associated with greater calcium absorption, higher bone mineral www.oldetowntimes.net/how-do-air-bubbles-work/ density, and a reduced chance of fractures. Further research with an overall design is needed to improve our understanding of how these genetic variations influence vitamin D supplementation and its clinical importance.